Table 4.
Association study with septic and nonseptic individuals among 646 major trauma patients
| Clinical characteristics | Number of patients or mean ± SD | Sepsis (n = 199) | Nonsepsis (n = 447) | X/t | P value |
|---|---|---|---|---|---|
| Age, years, mean ± SD | 41.8 ± 11.8 | 40.8 ± 7.4 | 42.2 ± 11.6 | −1.397 | 0.163 |
| Age range, years | 16–65 | 16–65 | 16–65 | ||
| Males/females, n | 523/123 | 159/40 | 364/83 | 0.210 | 0.665 |
| ISS, mean ± SD | 24.3 ± 6.7 | 26.4 ± 7.4 | 23.4 ± 6.1 | 5.007 | 0.000 |
| ≥ 16 to <25, n | 421 | 103 | 318 | 22.789 | 0.000 |
| ≥ 25, n | 225 | 96 | 129 | ||
| Severely injured body regions, n | |||||
| Head | 29 | 7 | 22 | 3.487 | 0.993 |
| Thorax | 99 | 28 | 71 | ||
| Abdomen | 119 | 37 | 82 | ||
| Extremities | 91 | 28 | 63 | ||
| Multiple | 308 | 99 | 209 | ||
| Organ dysfunction, n | |||||
| None | 261 | 81 | 180 | 1.328 | 0.725 |
| One, n | 177 | 53 | 124 | ||
| Two, n | 126 | 43 | 83 | ||
| Three or above, n | 82 | 22 | 60 | ||
| Source of infection, n (%) | |||||
| Respiratory tract | 293 | 89 | 204 | ||
| Primary bloodstream | 143 | 50 | 93 | ||
| Urinary tract | 103 | 33 | 70 | ||
| Catheter-associated | 40 | 10 | 30 | ||
| Wound | 40 | 11 | 29 | ||
| Others | 26 | 6 | 20 | ||
| Pathogens, n (%) | |||||
| Negative cultures | 337 | 82 | 255 | 23.841 | 0.001 |
| Gram-negative | 147 | 52 | 95 | ||
| Gram-positive | 101 | 40 | 61 | ||
| Fungi | 31 | 8 | 23 | ||
| Multiple infections | 30 | 17 | 13 | ||
| rs11666254, n (%) | |||||
| GG | 219 | 50 | 169 | 15.599 | 0.000 |
| GA | 310 | 98 | 212 | ||
| AA | 117 | 51 | 66 | ||
| GA + AA | 427 | 149 | 278 | 9.883 | 0.002 |
| GG + GA | 529 | 148 | 381 | 10.956 | 0.001 |
ISS Injury Severity Score, X/t Chi-square value/t value