Table 2.
Interaction terms between alcohol consumption and 29 urate loci for the risk of gout in New Zealand study cohorts
| SNP (% genotype data)a | Gene value | Effect allele | NZ European (n = 1039) | NZ Polynesian (n = 1753) | ||
|---|---|---|---|---|---|---|
| Interaction term (SE) | P value | Interaction term (SE) | P value | |||
| Alcohol intake as a continuous variable (per 50 g/week) | ||||||
| rs10821905 (99.2) | A1CF | A | 0.85 (0.07) | 0.026 | 1.09 (0.08) | 0.28 |
| rs2231142 (99.7) | ABCG2 | T | 0.99 (0.07) | 0.89 | 0.92 (0.05) | 0.19 |
| rs7976059 (98.9) | ACVR1B/ACVRL1 | T | 0.95 (0.07) | 0.44 | 0.94 (0.07) | 0.33 |
| rs653178 (99.3) | ATXN2 | G | 1.11 (0.07) | 0.15 | 1.07 (0.09) | 0.44 |
| rs11983997 (97.8) | MLXIPL/BAZ1B | G | 0.60 (0.22) | 0.022 | – | – |
| rs780094 (98.9) | GCKR | T | 0.76 (0.08) | 4.8 × 10−4 | 0.95 (0.06) | 0.33 |
| rs7224610 (99.2) | HLF | C | 0.97 (0.07) | 0.68 | 1.04 (0.06) | 0.59 |
| rs2941484 (98.9) | HNF4G | T | 0.98 (0.07) | 0.78 | 1.03 (0.06) | 0.64 |
| rs6598541 (99.0) | IGF1R | A | 0.92 (0.08) | 0.31 | 1.08 (0.16) | 0.61 |
| rs17050272 (99.0) | INHBB | A | 0.99 (0.07) | 0.96 | 0.98 (0.09) | 0.78 |
| rs1106766 (98.5) | INHBC | C | 0.90 (0.48) | 0.83 | 1.04 (0.17) | 0.84 |
| rs7188445 (98.8) | MAF | G | 1.14 (0.14) | 0.33 | 0.99 (0.08) | 0.98 |
| rs7193778 (98.8) | NFAT5 | C | 0.92 (0.08) | 0.30 | 1.12 (0.07) | 0.12 |
| rs1394125 (98.6) | UBE2Q2 | A | 1.13 (0.07) | 0.086 | 0.77 (0.12) | 0.024 |
| rs1967017 (99.0) | PDZK1 | T | 0.98 (0.08) | 0.85 | 1.01 (0.10) | 0.90 |
| rs10480300 (98.0) | PRKAG2 | T | 0.95 (0.07) | 0.45 | 1.17 (0.11) | 0.16 |
| rs675209 (99.2) | RREB1 | T | 0.83 (0.07) | 0.007 | 1.08 (0.15) | 0.61 |
| rs6770152 (98.8) | SFMBT1 | G | 0.98 (0.07) | 0.81 | 0.97 (0.07) | 0.72 |
| rs1183201 (99.5) | SLC17A1 | T | 0.96 (0.10) | 0.73 | 1.01 (0.10) | 0.91 |
| rs2078267 (99.7) | SLC22A11 | G | 0.98 (0.08) | 0.86 | 1.00 (0.22) | 1.00 |
| rs3825018 (99.7) | SLC22A12 | G | 0.89 (0.06) | 0.11 | 1.05 (0.11) | 0.67 |
| rs12356193 (98.3) | SLC16A9 | A | 1.07 (0.29) | 0.81 | – | – |
| rs11942223 (99.9) | SLC2A9 | T | 0.96 (0.21) | 0.85 | 0.52 (2.74) | 0.81 |
| rs17786744 (99.0) | STC1 | G | 1.08 (0.07) | 0.29 | 1.11 (0.06) | 0.055 |
| rs7953704 (99.2) | B3GNT4 | G | 0.99 (0.09) | 0.90 | 1.04 (0.07) | 0.52 |
| rs17632159 (98.6) | TMEM171 | G | 1.25 (0.14) | 0.10 | 0.86 (0.11) | 0.16 |
| rs11264341 (99.1) | TRIM46 | C | 1.01 (0.09) | 0.95 | 1.03 (0.06) | 0.63 |
| rs729761 (99.1) | VEGFA | G | 1.11 (0.14) | 0.46 | 0.99 (0.10) | 0.98 |
| rs2544390 (79.4) | LRP2 | T | 0.92 (0.09) | 0.34 | 0.72 (0.11) | 0.004 |
| Alcohol intake as a categorical variable (none vs. any intake) | ||||||
| rs10821905 (99.2) | A1CF | A | 0.29 (0.10) 0.28 (0.10)b 0.29 (0.11)c |
1.4 × 10−4
6.3 × 10−4 1.0 × 10−3 |
1.27 (0.36) | 0.40 |
| rs2231142 (99.7) | ABCG2 | T | 1.05 (0.38) | 0.88 | 0.91 (0.23) | 0.71 |
| rs7976059 (98.9) | ACVR1B/ACVRL1 | T | 0.75 (0.24) | 0.38 | 0.72 (0.19) | 0.22 |
| rs653178 (99.3) | ATXN2 | G | 1.90 (0.70) | 0.082 | 0.91 (0.79) | 0.79 |
| rs11983997 (97.8) | MLXIPL/BAZ1B | G | 0.19 (0.19) | 0.093 | – | – |
| rs780094 (98.9) | GCKR | T | 0.28 (0.09) 0.22 (0.08)b 0.23 (0.09)c |
1.5 × 10−4
5.8 × 10−58.5 × 10−5 |
0.62 (0.15) 0.54 (0.14) 0.53 (0.14) |
0.05 0.02 0.02 |
| rs7224610 (99.2) | HLF | C | 0.77 (0.25) | 0.43 | 1.26 (0.34) | 0.38 |
| rs2941484 (98.9) | HNF4G | T | 1.79 (0.62) | 0.092 | 1.36 (0.21) | 0.21 |
| rs6598541 (99.0) | IGF1R | A | 1.21 (0.40) | 0.57 | 1.32 (0.84) | 0.66 |
| rs17050272 (99.0) | INHBB | A | 0.49 (0.16) | 0.033 | 1.32 (0.46) | 0.43 |
| rs1106766 (98.5) | INHBC | C | 0.52 (0.36) | 0.35 | 1.54 (0.86) | 0.86 |
| rs7188445 (98.8) | MAF | G | 1.92 (1.07) | 0.24 | 0.98 (0.32) | 0.95 |
| rs7193778 (98.8) | NFAT5 | C | 0.63 (0.23) | 0.20 | 1.11 (0.31) | 0.70 |
| rs1394125 (98.6) | UBE2Q2 | A | 2.38 (0.79) | 0.009 | 0.63 (0.22) | 0.18 |
| rs1967017 (99.0) | PDZK1 | T | 0.83 (0.30) | 0.60 | 1.26 (0.48) | 0.54 |
| rs10480300 (98.0) | PRKAG2 | T | 1.07 (0.34) | 0.83 | 1.01 (0.42) | 0.97 |
| rs675209 (99.2) | RREB1 | T | 0.68 (0.22) | 0.23 | 1.33 (0.75) | 0.61 |
| rs6770152 (98.8) | SFMBT1 | G | 1.26 (0.44) | 0.51 | 1.07 (0.32) | 0.82 |
| rs1183201 (99.5) | SLC17A1 | T | 0.53 (0.22) | 0.12 | 1.80 (0.83) | 0.20 |
| rs2078267 (99.7) | SLC22A11 | G | 1.20 (0.42) | 0.60 | 0.60 (0.55) | 0.58 |
| rs3825018 (99.7) | SLC22A12 | G | 1.27 (0.40) | 0.45 | 1.00 (0.41) | 0.99 |
| rs12356193 (98.3) | SLC16A9 | A | 1.03 (0.99) | 0.97 | – | – |
| rs11942223 (99.9) | SLC2A9 | T | 0.83 (0.71) | 0.82 | 1.12 (2.96) | 0.97 |
| rs17786744 (99.0) | STC1 | G | 1.00 (0.34) | 0.99 | 1.72 (0.43) | 0.03 |
| rs7953704 (99.2) | B3GNT4 | G | 1.28 (0.52) | 0.54 | 0.68 (0.24) | 0.27 |
| rs17632159 (98.6) | TMEM171 | G | 1.71 (1.02) | 0.37 | 0.38 (0.16) | 0.022 |
| rs11264341 (99.1) | TRIM46 | C | 1.45 (0.59) | 0.36 | 1.07 (0.27) | 0.80 |
| rs729761 (99.1) | VEGFA | G | 1.81 (0.97) | 0.26 | 0.99 (0.41) | 0.97 |
| rs2544390 (79.4) | LRP2 | T | 0.86 (0.34) | 0.71 | 0.32 (0.12) | 0.003 |
NZ New Zealand, SNP Single-nucleotide polymorphism
Regression analyses are adjusted for age, sex, and body mass index. The Polynesian analyses are additionally adjusted for STRUCTURE ancestry and ancestral class (Western vs. Eastern Polynesian vs. mixed Western/Eastern Polynesians). No data are presented for rs11983997 and rs12356193 in people of Polynesian ancestry, owing to the minor genotype group having very low frequency (<0.01)
aFor each individual SNP, the number inside the parentheses represents the percentage of subjects with available genotype data
bThe interaction term was additionally adjusted for triglycerides (mmol/L)
cThe interaction term was additionally adjusted for estimated glomerular filtration rate (ml/minute/1.73 m2)