Table 2.
Compounds SNS-032 (MMV690767) and AG-1295 (MMV079840) were tested for toxic effects on breast epithelial (MCF10A) cells. Selectivity indices of these compounds on the motility of exsheathed third-stage larvae (xL3) and fourth-stage larvae (L4) of Haemonchus contortus (after 72 h of exposure to the compound) and the development of L4s (over 7 days of exposure) were calculated using a recognized formula [38]
| Compound | IC50 (μM) for MCF10A cells | Selectivity indices for H. contortus | ||
|---|---|---|---|---|
| xL3 motility (72 h) | L4 motility (72 h) | L4 development (7 days) | ||
| SNS-032 | 1.3 | nd | nd | 0.04 |
| AG-1295 | > 100 | 10.1a | nd | 10.9a |
| Monepantel | 27.8 | 173.6 | 75.1 | 370.3 |
Abbreviation: nd not determined
aSelectivity indices were calculated based on the highest value in the IC50 range