Fig. 1.

Illustrative description of the two sets of ELISPOT data derived from MTB epitopes and how they were used. The left panel shows the response data obtained when reactivity of each of the 191 peptides was determined in a set of 87 HLA typed donors and was used to infer restrictions by the RATE approach. The right panel shows the HLA restriction of the same 191 peptides in 63 donors determined experimentally using HLA transfected cell lines. This data was then screened and used for validation of RATE by comparing with RATE results from the first data set