Figure 5.

Effects of gene deletions affecting the DNA damage checkpoint pathway across a range of telomere defective backgrounds. (A) Profilyzer fitness profiles comparing the effects of ddc1∆, rad24∆, rad17∆, rad9∆, and chk1∆ mutations on fitness across all the screens presented in Figure 1, Figure 2, and Figure 3. (B) List of gene deletions with most similar fitness profiles to rad17∆ out of ∼5000 examined, including rad9∆ (position 27) and chk1∆ (position 82). (C, D) Yeast cultures treated as in Figure 4B.