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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Lancet Haematol. 2017 Mar 15;4(4):e176–e182. doi: 10.1016/S2352-3026(17)30028-5

Table 2.

Adverse Events, Serious or Life-threatening Adverse Events (grades 3/4), and Key Laboratory Abnormalities (n=11) occurring in at least two patients OR greater than grade 2 are included.

A051202 A051202
Grade 1–2 Grade 3 Grade 4 Grade 1–2 Grade 3 Grade 4
Anemia 2 (67%) 0 0 6 (75%) 0 0
Lymphocyte count decreased 2 (67%) 0 0 2 (25%) 5 (63%) 1 (13%)
Neutrophil count decreased 1 (33%) 1 (33%) 0 4 (50%) 1 (13%) 0
Platelet count decreased 3 (100%) 0 0 3 (38%) 1 (13%) 0
White blood cell decreased 2 (67%) 0 0 3 (38%) 0 0
Constipation 0 0 0 3 (38%) 1 (13%) 0
Diarrhea 0 0 0 3 (38%) 0 0
Mucositis oral 2 (67%) 0 0 1 (13%) 0 0
Fatigue 2 (67%) 0 0 6 (75%) 1 (13%) 0
Fever 1 (33%) 0 0 3 (38%) 1 (13%) 0
Lung infection 0 0 0 0 2 (25%) 0
Alanine Aminotransferase increased 0 1 (33%) 1 (33%) 5 (63%) 0 0
Alkaline phosphatase increased 0 0 0 2 (25%) 0 0
Aspartate aminotransferase increased 1 (33%) 0 1 (33%) 3 (38%) 0 0
Hyperglycemia 0 0 0 2 (25%) 1 (13%) 0
Hyperuricemia 0 0 0 2 (25%) 0 0
Hypoalbuminemia 1 (33%) 0 0 3 (38%) 0 0
Hypocalcemia 2 (67%) 0 0 1 (13%) 0 0
Hyponatremia 0 0 0 2 (25%) 0 0
Hypophosphatemia 1 (33%) 0 0 2 (25%) 1 (13%) 0
Rash maculopapular 0 2 (67%) 0 1 (13%) 4 (50%) 0