Table 1.

Associations supported by meta-analytic evidence

Antecedent	Outcomes	Meta-analytic support
PTSD	CVD events
	Incident CHD	HR= 1.55 (95% CI 1.34–1.79); with adjustment for depression, HR= 1.27 (95% CI 1.08–1.49) Edmondson et al., 2013
	Incident stroke/TIA	RR= 2.36 (95% CI 2.11–2.65) Emdin et al., 2016
	Incident VTE	No
	Recurrent MI/unstable angina/mortality	RR= 2.0 (95% CI, 1.69–2.37) Edmondson et al., 2013
	Recurrent stroke/TIA	No
	Mechanisms
	Type 2 diabetes	RR = 1.49, 95% CI = 1.17–1.89) Vancampfort et al., 2016
	Metabolic syndrome	OR= RR = 1.82; 95% CI = 1.72 –.92 Rosenbaum et al., 2015
	Blood pressure	Systolic; Unweighted d (SE)= .13 (.07) Diastolic; Unweighted d (SE) = .39 (.21) Buckley et al., 2001
	Inflammation	Greater IL-1β, IL-6, and interferon γ in PTSD Passos et al., 2015
	Cortisol	Unclear Klassens et al., 2012; Morris et al., 2012
	Endothelial dysfunction	No
	Obesity	OR = 1.35 (95% CI 1.05–1.74) Bartoli et al., 2015
	Smoking	6/7 studies showed positive associations; ORs ranged 2.04–4.52 Fu et al., 2007
	Sleep	No
	Medication nonadherence	No
ACS	PTSD	12% screen positive (95% CI, 9%–16%) Edmondson et al., 2013
Stroke/TIA		23% screen positive (95% CI, 16–33%) Edmondson et. al., 2013
VTE		No