Figure 8.

Example of a haplotype-specific recombination coldspot at the Igh locus. (A) Cumulative recombination map for COs involving (pink) or not involving (gray) the 129S1/SvImJ haplotype in the vicinity of the Igh locus on distal chromosome 12. Maps are scaled to arbitrary units so that both start at zero and end at one. Extent of 129S1/SvImJ-specific coldspot is indicated by gray bar. (B) Dotplot representation of alignment of GL456017.2 (alternate sequence derived from 129S1/SvImJ BACs) to the mouse reference genome. (C) CNVs in the vicinity of the Igh locus. Alleles private to each strain are shown in individual tracks; alleles shared by two or more strains are shown in top track.