Table 9. Genetically induced and chemically induced slowed cell cycle in cdc13 (-F684s).
| Genotype | Unstable Chr. (×10−5) | Allelic rec. (×10−5) | Chr. loss (×10−4) | ||||
|---|---|---|---|---|---|---|---|
| Median (Q1, Q3) | Fold stabil. | Median (Q1, Q3) | Fold stabil. | Median (Q1, Q3) | Fold stabil. | ||
| cdc13 30° | 49 (37, 69) | 1 | 7.3 (4.0, 22) | 1 | 4.8 (3.1, 12) | 1 | |
| ChrVII RAD+ (wild type) | 6.0 (3.5, 7.6) | 8.2* | 6.8 (3.5, 10) | 1.07 | 3.7 (1.1, 5.2) | 1.3 | |
| Genetically slowed cell cycle | cdc13 erv14 30° | 6.2 (3.7, 8.7) | 7.9* | 2.2 (1.1, 4.5) | 3.3* | 2.2 (1.1, 4.2) | 2.20 |
| D-glucosamine | cdc13 2% Dex, 0.7% D-gluc 30° | 23 (21, 37) | 2.10 | 0.0 (0.0, 0.88)* | N/A | 0.59 (0.0, 2.3) | 8.1* |
| cdc13 2%Dex, 1.4% D-gluc 30° | 13 (0.0, 19) | 3.8* | 1.3 (0.0, 3.1) | 5.6* | 4.0 (1.6, 6.3) | 1.20 | |
| Myriocin | cdc13 400 ng/ml Myr. 30° | 18 (12, 24) | 2.7* | 13 (10, 27) | 0.56* | 2.7 (2.2, 4.7) | 1.80 |
| cdc13 800 ng/ml Myr. 30° | 13 (11, 15) | 3.8* | 7.6 (5.9, 8.4) | 0.96 | 3.2 (2.4, 3.3) | 1.50 | |
Instability frequencies and genome fold stabilization for genetically induced and chemically induced slowed cell cycle stabilization in cdc13 normalized to cdc13 grown on YEPD media plates. Instability frequencies and genome fold stabilization of cdc13 erv14 in the temperature shift single cell cycle experiment normalized to cdc13. Experiment was performed in triplicate. Cells with a light gray background indicate genome fold stabilization increase; cells with a white background indicate decreased fold stabilization (<1.0 = increased instability) or no change in stabilization (=1.0). Statistically significant appears in boldface type. Kruskal–Wallis test, * P < 0.01.