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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Nature. 2016 Nov 10;539(7628):242–247. doi: 10.1038/nature20111

Extended Data Figure 6. OSTN is primarily expressed in the neocortex of human brain.

Extended Data Figure 6

BrainSpan (http://www.brainspan.org) RNA-seq data showing expression levels of OSTN (red) and BDNF (grey) in 6 human brain regions (a–f; neocortex, hippocampus (HIP), amygdala (AMY), striatum (STR), mediodorsal nucleus of the thalamus (MD), and cerebellar cortex (CBC)) and OSTN in subregions of the human cortex from 8 pcw through 40 years old (g). Loess-fit curves depict mean expression with bands showing one s.e.m. h, FISH images showing OSTN expression in a radial section of human fetal brain (pcw16) illustrating selective enrichment of OSTN in the developing cortical plate of the paracentral lobule. Isolated OSTN signal also appears to be localized to migrating neurons (arrowheads) of the subplate. Scale bar, 200 μm. MZ, marginal zone; CP, cortical plate; SP, subplate; IZ, intermediate zone; SVZ, subventricular zone; VZ, ventricular zone.