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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Nature. 2016 Nov 10;539(7628):242–247. doi: 10.1038/nature20111

Extended Data Figure 8. Luciferase reporter constructs and the complete set of assays.

Extended Data Figure 8

a, Detailed summary of all luciferase assay reporter construct variants of the human genomic sequence –2 kb upstream of the OSTN transcription start site. b, Summary of all luciferase assays performed in mouse cortical cultures. Categories of construct modifications are indicated and grouped by colour. Biological replicate numbers are indicated on the graph. Significant differences tested for by one-way ANOVA DF = (33, 266) and P < 1.0 × 10–13. Pair-wise comparisons were made using Holm–Sidak test for multiple comparisons using an overall error rate of 0.05, ***P < 1.22 × 10–5. All values are mean ± s.e.m.