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. 2017 Jul 6;8:1128. doi: 10.3389/fpsyg.2017.01128

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Copyright © 2017 Lee, Coehlo, Solton and Szumlinski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreases in glutamate-related protein expression within the CeA following single-bottle drinking. In a 14-day pilot study of single-bottle (20% EtOH) drinking in adults, animals consumed an average of 3.12 ± 0.18 g/kg. (A) Alcohol drinkers showed a significant decrease in mGlu1 expression within the CeA at 24 h withdrawal. (B) A similar negative trend was observed in Homer 2 expression. ^∗p < 0.05 vs. water controls. Data represent mean + SEM of the number of animals indicated in parentheses. Unequal sample sizes due to sample availability, not outlier exclusion.