Figure 2. Pharmacological inhibition of SOCS1 or SOCS1 deficiency increases the systemic proinflammatory response in septic mice.

Quantification of IL-6 and TNF-α levels in serum from mice treated with inhibitor of the kinase inhibitory region (iKIR) or control peptide (A and B), and from Socs1^Δmyel and Socs1^fl mice (C and D) 18 hours after the onset of sepsis. Scatter plot shows individual values, mean, and SEM. *P < 0.05, control septic mice vs. naive, or Socs1^fl septic mice vs. naive; ^#P < 0.05, iKIR-treated septic mice vs. naive, or Socs1^Δmyel septic mice vs. naive; ^&P < 0.05 iKIR-treated septic mice vs. control-treated septic mice, or Socs1^Δmyel septic mice vs. Socs1^fl septic mice. In all circumstances, n = 4–7 mice/group and 1-way ANOVA followed by Bonferroni correction.