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. 2017 Jul 6;2(13):e92530. doi: 10.1172/jci.insight.92530

Figure 3. SOCS1 inhibits lung injury during sepsis.

Figure 3

(A) Socs1 expression in the lung of septic mice was quantified 18 hours after cecal ligation and puncture (CLP) (n = 8–9 mice/group, unpaired t test). (B) Quantification of lung volume in inhibitor of the kinase inhibitory region–treated (iKIR-treated) septic mice 18 hours after CLP by microCT analysis (n = 6–7 mice/group, unpaired t test). (C) Histological analysis with H&E staining of lung tissue from Socs1Δmyel and Socs1fl septic and their respective naive mice (original magnification, ×100). (D) Detection of Ly6G+ neutrophils in Socs1Δmyel and Socs1fl mice, 18 hours after the onset of sepsis. Original magnifications, ×100 and ×400. (E) Pulmonary myeloperoxidase (MPO) activity in the lung of iKIR-treated septic mice. (F) KC and (G) IL-6 production in the lung of iKIR-treated septic mice. E: n = 4 mice/group, t test, Mann-Whitney U test. F: n = 4–5 mice/group, unpaired t test. Scatter plot shows individual values, mean, and SEM. *P < 0.05, iKIR-treated vs. control or naive mice.