Figure 6. T cell SGK1 deficiency attenuates hypertension and vascular inflammation in a DOCA-salt model of hypertension.

(A) Systolic blood pressures measured noninvasively using the tail-cuff method in SGK1^fl/fl and SGK1^fl/fltg^CD4cre mice in response to deoxycorticosterone acetate–salt (DOCA-salt) treatment over 21 days. *P < 0.05, **P < 0.01; regression analysis; n = 8–10 per group. (B–F) Summary flow cytometry data of absolute numbers of total leukocytes (CD45⁺ cells), total T lymphocytes (CD45⁺CD3⁺ cells), and monocytes/macrophages (CD45⁺F4/80⁺ cells) per thoracic aorta in SGK1^fl/fl and SGK1^fl/fltg^CD4cre mice after 21 days of DOCA-salt or vehicle (sham) treatment. *P < 0.05, **P < 0.01; 2-way ANOVA/Holm-Sidak’s post-hoc test; n = 8–14 per group. All data are expressed as mean ± SEM.