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. 2017 Jul 6;2(13):e92282. doi: 10.1172/jci.insight.92282

Figure 7. The actions of exendin-4 and metformin on pancreatic duct glands (PDGs) and interlobular duct replication in human-IAPP-transgenic (HIP) rats and WT controls.

Figure 7

(A and B) Twelve weeks of treatment with the glucagon-like peptide-1 mimetic exendin-4 (Ex) induced an increase in PDG (A) and interlobular duct (B) cell replication in control WT rats and caused a further increase in replication in HIP rats. Metformin (Metf) treatment over the same 12 weeks suppressed the Ex-induced proliferation in WT and HIP rats in both PDGs and interlobular ducts. WT n = 5, WT+Ex n = 6, WT+Metf n = 6, WT+Ex+Metf n = 6, HIP n = 6, HIP+Ex n = 6, HIP+Metf n = 6, HIP+Ex+Metf n = 6. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus WT saline control by 1-way ANOVA with Dunnett’s post-hoc test.