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Steady-state ROS-induced DNA base damage increases in chronic UVB irradiated WT and in Neil1−/− mice. Levels of ROS-induced DNA base lesions were measured by GC-MS/MS. FapyAde (Panel a), FapyGua (Panel b), ThyGly (Panel c), 5,6-diOH-Ura (Panel d), and 8-OH-Gua (Panel e) were measured. Data are presented as mean ± SD. WT, n = 5; Neil1−/−, n = 5; ** p < 0.01 compared to un-irradiated of same genotype. # p < 0.05 and ## p < 0.01 compared to WT.
