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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Math Biosci. 2010 Mar 25;226(1):1–15. doi: 10.1016/j.mbs.2010.03.005

Fig. 13.

Fig. 13

Schematic representation of the common methods used for modeling CICR in cardiac myocytes. Filled circles and solid lines represent compartments and fluxes, respectively. The ellipsis in the Monte Carlo diagram indicates a large number (N) calcium release units. The ellipsis in the 2D and 1D probability density diagram indicate the number of states (M) in the Markov chain (MC) used to represent the two calcium channels in the release site. Similarly, the index i in the moment closure diagram indexes into the M states of the release site. Values contained with square brackets indicate the relative computational complexity of the various techniques where N is the number of releases sites, M is the number of states in the Markov chain, and L is the length of the mesh required to represent the densities.