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. 2017 May 30;45(12):7494–7506. doi: 10.1093/nar/gkx362

Figure 1.

Figure 1.

Crystal structure of A3B-CD1m. (A) Two views of the 1.9 Å monomer structure of A3B-CD1m, related by 90° rotation. Secondary structure nomenclature is as described previously (84). (B and C) Superimposition of A3B-CD1m (green) with the crystal structure of A3B-CD2 (49) (magenta) in secondary structures (B) and zinc-coordinated active center (C). The beginning of α4 of A3B-CD1 breaks into a small 310 helix α4΄ (B). (D) Electron density map of A3B-CD1m around active center, contouring at 1.0σ level. (E) Structural comparison of loop-3 (LP3) between A3B-CD1m (green), Z1 (A3A (66), A3G-CD2 (33), orange) and Z2 (A3F-CD2c (63), A3C (62), rA3G-CD1 (27), white) domains. Dashed box indicates loop-3. (F) Structural comparison of loop-7 (LP7) and α4 between A3B-CD1m (green) and rA3G-CD1 (cyan). The α4΄ at the beginning of α4 on A3B-CD1m is labeled. (G) Model of A3B-CD1 WT based on A3B-CD1m structure. Four surface tyrosine residues (magenta) and W127 (orange) mutated in A3B-CD1m are shown as magenta sticks.