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. 2017 Apr 29;45(12):7180–7190. doi: 10.1093/nar/gkx321

Figure 2.

Figure 2.

Chromodomain Helicase DNA Binding Protein 1 (CHD1) affects domains of H3K4me3 and H3K36me3. (A) Genome browser views of H3K4me3 and H3K36me3 across the SEC23 and EFT1 genes in WT and chd1Δ strains. (B) Average H3K4me3 and H3K36me3 profiles for all yeast genes for two replicate experiments from 500 bp upstream to 1500 bp downstream of the TSS. The dark line is the mean and the shaded envelope indicates the 95% confidence interval of the mean H3K4me3/H3K36me3 ChIP-seq read signal (RPM) for all genes. H3K4me3 and H3K36me3 signals in WT are colored sky blue and pink, respectively. H3K4me3 and H3K36me3 signals in chd1Δ are colored dark blue and purple, respectively. The inset for replicate 2 highlights the region between 500 and 700 bp downstream of the TSS to show the shift of H3K4me3 and H3K36me3 domain boundaries toward the TSS.