Table 1.
Baseline characteristics of cohortsa
| Characteristic | Mild | Severe | ||||
|---|---|---|---|---|---|---|
| Controls (N = 50,309) | Psoriasis (N = 10,115) | Mild psoriasis vs control, p value | Controls (N = 19,051) | Psoriasis (N = 3821) | Severe psoriasis vs control, p value | |
| Age at diagnosis, years | ||||||
| Mean (SD) | 57.6 (14.84) | 57.1 (14.86) | 0.011 | 52.9 (13.67) | 52.4 (13.68) | 0.058 |
| Median (IQR) | 58 (48–68) | 58 (47–68) | 54 (44–62) | 53 (44–62) | ||
| Age category, years | ||||||
| < 45 | 9552 (19.0) | 1987 (19.6) | 0.17 | 4905 (25.7) | 1023 (26.8) | 0.462 |
| 45–54 | 10,378 (20.6) | 2133 (21.1) | 5186 (27.2) | 1048 (27.4) | ||
| 55–64 | 13,527 (26.9) | 2700 (26.7) | 5150 (27) | 1016 (26.6) | ||
| ≥ 65 | 16,852 (33.5) | 3295 (32.6) | 3810 (20) | 734 (19.2) | ||
| Sexb | ||||||
| Women | 26,559 (52.8) | 5343 (52.8) | 9441 (49.6) | 1894 (49.6) | ||
| Men | 23,750 (47.2) | 4772 (47.2) | 9610 (50.4) | 1927 (50.4) | ||
| Ethnicity | ||||||
| Missing | 1912 (3.8) | 362 (3.6) | < 0.001 | 763 (4.0) | 129 (3.4) | < 0.001 |
| White | 23,369 (46.5) | 5829 (57.6) | 8568 (45.0) | 2025 (54.8) | ||
| Black | 5606 (11.6) | 467 (4.6) | 2196 (12) | 206 (5.6) | ||
| Hispanic | 13,516 (27.9) | 2348 (23.2) | 5326 (29.1) | 906 (24.5) | ||
| Asian/Pacific Islander | 4858 (10) | 911 (9.0) | 1783 (9.7) | 489 (13.2) | ||
| Other | 1048 (2.2) | 198 (2.0) | 415 (2.3) | 66 (1.8) | ||
| Hypertension | ||||||
| No | 25,495 (50.7) | 4729 (46.8) | < 0.001 | 11,467 (60.2) | 1976 (51.7) | < 0.001 |
| Yes | 24,814 (49.3) | 5386 (53.2) | 7584 (39.8) | 1845 (48.3) | ||
| Dyslipidemia | ||||||
| No | 25,858 (51.4) | 4833 (47.8) | < 0.001 | 11,875 (62.3) | 2322 (60.8) | 0.069 |
| Yes | 24,451 (48.6) | 5282 (52.2) | 7176 (37.7) | 1499 (39.2) | ||
| Diabetes | ||||||
| No | 41,465 (82.4) | 8043 (79.5) | < 0.001 | 16,335 (85.7) | 3129 (81.9) | < 0.001 |
| Yes | 8844 (17.6) | 2072 (20.5) | 2716 (14.3) | 692 (18.1) | ||
| Lipid medication | ||||||
| No | 31,015 (61.6) | 5945 (58.8) | < 0.001 | 13,550 (71.1) | 2612 (68.4) | < 0.001 |
| Yes | 19,294 (38.4) | 4170 (41.2) | 5501 (28.9) | 1209 (31.6) | ||
| Hypertension medication | ||||||
| No | 22,889 (45.5) | 4228 (41.8) | < 0.001 | 10,402 (54.6) | 1809 (47.3) | < 0.001 |
| Yes | 27,420 (54.5) | 5887 (58.2) | 8649 (45.4) | 2012 (52.7) | ||
| Statin medication | ||||||
| No | 31,059 (61.7) | 5951 (58.8) | < 0.001 | 13,557 (71.2) | 2618 (68.5) | < 0.001 |
| Yes | 19,250 (38.3) | 4164 (41.2) | 5494 (28.8) | 1203 (31.5) | ||
| Beta-blocker medication | ||||||
| No | 35,669 (70.9) | 6836 (67.6) | < 0.001 | 14,769 (76.9) | 2755 (71.7) | < 0.001 |
| Yes | 14,640 (29.1) | 3279 (32.4) | 4436 (23.1) | 1086 (28.3) | ||
| Diabetes medication | ||||||
| No | 42,759 (85) | 8315 (82.2) | < 0.001 | 16,682 (87.6) | 3184 (83.3) | 0.0001 |
| Yes | 7550 (15) | 1800 (17.8) | 2369 (12.4) | 637 (16.7) | ||
a
Data are number (percentage) unless otherwise indicated.
b
Study groups were matched by sex, so it is not appropriate to calculate a p value for the comparison.
IQR = interquartile range; SD = standard deviation.