Fig. 1.

Male-specific social impairments in TERT transgenic mice. (A, B) Sociability test. The total duration in each chamber (A) and duration of sniffing to wire cages (B) in the presence of a stranger mouse in one wire cage were compared between male and female TERT-tg mice versus the control groups. (C, D) Social novelty preference test. The total duration in each chamber (C) and the length of sniffing to wire cages (D) in the presence of a familiar or novel mouse were also evaluated. All data are expressed as the mean ± SEM. One male, and one female mouse was chosen from each of 10 litters for a total 10 mice per group. ^*p<0.05, ^***p<0.001 vs. FVB male group; ^#p<0.05, ^##p<0.01, ^###p<0.001 vs. TERT-tg female group, as revealed by Bonferroni’s posthoc comparisons following two-way ANOVA.