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Mean read-counts (log-scale) for PpsA in WT versus the KO of Rv2680. Read-counts in the WT strain exhibit a slight increase after passage through mice for 32 days. On the other hand, a 10-fold decline is observed for the KO strain after 32 days, suggesting PpsA is essential for virulence in the absence of Rv1432. Other PDIM biosynthesis genes exhibited similar declines in the KO strain.
