Table 1. Genes selected for this study that are non-essential in vitro but for which transposon insertion causes attenuation in vivo.
| Gene | In vitro | In vivo | Fold-change | log FC | P-val |
|---|---|---|---|---|---|
| Rv2680 | 881.3 | 116.8 | 0.132 | −2.92 | 0 |
| Rv1432 | 774.4 | 6 | 0.008 | −7.02 | 0 |
| Rv1565c | 2115.6 | 244.4 | 0.116 | −3.11 | 0 |
The data shown are normalized insertion counts from a Tn-Seq experiment with an H37Rv transposon library, averaged over two replicates for each condition. ‘log FC’ is the enrichment, calculated as log2(in vivo/in vitro). The P-value is based on comparison to a simulation of the null distribution by permuting the counts between conditions in each gene (7).