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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: J Med Chem. 2016 Aug 29;59(17):8134–8140. doi: 10.1021/acs.jmedchem.6b00753

Scheme 1. Synthetic Route for Fulvestrant-3 Boronic Acida.

Scheme 1

a(a) Triflic anhydride, pyridine in DCM, −10 °C; (b) bis(pinacolato)-diboron, Pd(OAc)2, and tricyclohexylphosphine in CH3CN, 80 °C; (c) KOH in CH3OH and THF; (d) meta-chloroperoxybenzoic acid in DCM, 0 °C.