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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: J Med Chem. 2016 Aug 29;59(17):8134–8140. doi: 10.1021/acs.jmedchem.6b00753

Table 1.

Effects of 5 on Proliferation of Breast Cancer Cells

cell line IC50 (μM)
4-OHT fulvestrant 5
MCF-7 0.0033 0.0015 0.0032
T47D 0.024 0.0012 0.0061
MCF-7/TamR 22 0.044 0.069
T47D/PKCα 0.54 0.042 0.037