Table 1.

Baseline characteristics. Abbreviations: HAT- hemorrhage after thrombolysis; ICA – internal carotid artery; US-United States; UK-United Kingdom.

Variable	Control rt-PA-alone N=29	Low-Dose Argatroban + rt-PA N=30	High-Dose Argatroban + rt-PA N=31
Age mean±SD	69±15	71±15	67±13
Male N(%)	17(59)	17(57)	16(52)
Ethnicity N(%)
Caucasian	15(52)	13(43)	15(48)
Hispanic	2(7)	4(13)	4(13)
Black	11(38)	13(43)	11(36)
Asian	1(3)	0(0)	1(3)
Stroke Onset to rt-PA bolus, minutes mean±SD	114±43	134±52	114±46
Baseline NIHSS median (IQR), range	15 (11,20), 4–26	16 (11,21), 2–29	13 (7,17), 3–33
Glucose median, range	123, 69–418	130, 88–309	125, 86–494
aPTT, mean±SD, range	27±5, 10–36	28±4, 13–36	29±3, 20–34
Antithrombotic medications N(%)
Aspirin	11(38)	7(24)	12(39)
Clopidogrel	2(7)	1(4)	2(7)
Warfarin	1(4)	2(7)	1(3)
Dabigatran	0	0	1(3)
Past Medical History N(%)
Prior Stroke	3(10)	3(10)	5(16)
Hypertension	25(86)	24(80)	25(81)
Coronary Artery Disease	1(4)	3(10)	1(3)
Diabetes mellitus	6(21)	10(33)	0(29)
Congestive Heart Failure	6(21)	1(3)	6(19)
Atrial Fibrillation	5(17)	7(23)	11(36)
Hypercholesterolemia	8(30)	16(55)	11(39)
Current Smoker	8(28)	5(18)	6(20)
ASPECTS score median (IQR), range	10 (8,10), 3–10	8 (6,10), 1–10	9 (8,10), 3–10
Stratification Variables N(%)
HAT score
0–2 (low-risk)	25(86)	25(83)	26(84)
3–5 (high-risk)	4(14)	5(17)	5(16)
Terminal ICA occlusion
Present	3(10)	4(13)	3(10)
Not-present	18(62)	18(60)	21(68)
N/A - No vessel imaging	8(28)	8(27)	7(23)
Site
US sites	21(72)	22(73)	22(71)
UK sites	8(28)	8(27)	9(29)
Vessel Occlusion N(%)*	N=11	N=20	N=15
MCA (M1 or proximal M2)	9(82)	16(80)	13(87)
Terminal ICA	2(18)	2(10)	2(13)
Vertebrobasilar	0	2(10)	0

^*Vessel imaging required if baseline NIHSS was <10. Modalities: CT-Angiogram=80%; TCD=20%.