Table 2.

Primary and secondary outcome results. All regression analyses adjusted for stratification variables. Abbreviations: CrI–credible interval, CI–confidence interval.

	Control rt-PA-alone N=29	Low-Dose Argatroban + rt-PA N=30	High-Dose Argatroban + rt-PA N=31	Low + High-Dose Argatroban + rt-PA N=61
PRIMARY OUTCOME
mRS 0–1 at 90-days N(%)	6(21)	9(30)	10(32)	19(31)
RR (95% CrI), probability RR>1.0	–	1.17 (0.57, 2.37), 0.67	1.27 (0.63, 2.53), 0.74	1.34 (0.68, 2.76), 0.79
SECONDARY OUTCOMES
Symptomatic Intracerebral Hemorrhage N(%)	3(10)	4(13)	2(7)	6(10)
RR (95% CrI), probability RR>1.0	–	1.55 (1.07, 2.25), 0.99	1.73 (1.04, 2.89), 0.98	–
Recanalization at 2–3 hours	N=11	N=20	N=15	N=35
Complete N (%)	2(18)	3(15)	4(27)	7(20)
RR (95% CrI), probability RR>1.0	–	0.98 (0.61, 1.56), 0.46	1.05 (0.66, 1.68), 0.58	1.02 (0.64, 1.63), 0.53
Complete + Partial N (%)	6(55)	4(20)	7(47)	11(31)
RR (95% CrI), probability RR>1.0	–	0.86 (0.55, 1.33), 0.25	1.06 (0.68, 1.65), 0.60	0.92 (0.59, 1.43), 0.35
Neurological Improvement, NIHSS, median (IQR)
RR (95% CrI), probability RR>1.0
2-hours	11 (6,19) N=29	14.5 (5,18) N=28	11 (4,16) N=31	13 (5,18) N=59
	–	1.11 (0.78, 1.58), 0.73	0.94 (0.66, 1.33), 0.36	1.02 (0.74, 1.39), 0.55
24-hours	10 (5,18) N=29	14 (3,20) N=29	9 (4,16) N=31	11.5 (3.5,18) N=60
	–	1.19 (0.79, 1.81), 0.79	0.94 (0.62, 1.42), 0.38	1.06 (0.72, 1.54), 0.62
48-hours	8 (3,18) N=27	10 (4,21) N=29	10 (2,17) N=31	10 (2.5,20) N=60
	–	1.19 (0.76, 1.88), 0.78	0.97 (0.61, 1.53), 0.44	1.09 (0.71, 1.63), 0.65
Day 7	5 (3,14) N=27	10.5 (3,18) N=30	6 (2,14) N=29	9 (2,16) N=59
	–	1.17 (0.7, 1.98), 0.72	0.9 (0.53, 1.53), 0.34	1.03 (0.64, 1.66), 0.55
Day 90	2.5 (1,8) N=24	5.5 (1.5,12.5) N=24	2 (1,7) N=25	3 (1,12) N=49
	–	1.33 (0.73, 2.42), 0.83	1.02 (0.55, 1.88), 0.52	1.21 (0.68, 2.1), 0.75
Quality of Life at 90-days, median (IQR)
EuroQol EQ-5D utility	0.62 (0,0.82) N=29	0.38 (0.05,0.79) N=28	0.64 (0.18,0.84) N=29	0.48 (0.12,0.83) N=57
Standard Gamble utility	0.83 (0.45,0.98) N=27	0.68 (0.05,0.94) N=27	0.88 (0.50,0.95) N=28	0.78 (0.45,0.94) N=55
Visual Analogue Scale (converted to 0–1 scale)	0.50 (0.28,0.75) N=28	0.42 (0.22,0.80) N=28	0.60 (0.50,0.85) N=29	0.50 (0.30,0.80) N=57