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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Trends Genet. 2017 May 19;33(7):479–489. doi: 10.1016/j.tig.2017.04.006

Figure 1. RAG DSBs Employ Distinct Signaling Pathways to Activate a Multifunctional Genetic Program that Transcends the Cellular DSB Response.

Figure 1

RAG DSBs induced at Igκ loci in pre-B cells signal through ATM-independent and ATM-dependent pathways, the latter involving canonical and non-canonical NFκB pathways, to control the levels of transcripts from numerous genes. Many of these genes encode proteins that regulate lymphocyte development and function. Representative genes regulated downstream of defined or undefined signaling pathways are indicated.