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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Trends Genet. 2017 May 19;33(7):479–489. doi: 10.1016/j.tig.2017.04.006

Figure 2. RAG DSBs Activate Signals that Prolong Survival of Immature Lymphocytes Assembling AgR Genes.

Figure 2

A. RAG Igκ DSBs induced in pre-B cells signal via ATM/p53 to transcriptionally activate the pro-apoptotic BAX protein and via ATM/NFκB to transcriptionally activate the Pim2 kinase. Pim2 promotes phosphorylation and inactivation of the pro-apoptotic BAD protein, which blocks BAX-induced cell death. B. RAG DSBs induced at Tcrb loci in DN thymocytes promote ATM-mediated phosphorylation and activation of p38MAPK, which in turn phosphorylates and inactivates the pro-apoptotic GSK3p kinase.