Table 9.

Accumulation of iodine radioactivity in the thyroid for compounds 27, 46, and the isomers of compound 47

	2 min	15 min	0.5 h	1 h	2 h	3 h	24 h	48 h	72 h	Ref.
27 a	n.a.	n.a.	n.a.	3.2 ± 0.98	n.a.	14 ± 2	19 ± 3	23 ± 6	n.a.	70
46 b	0.09 ± 0	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0	n.a.	n.a.	n.a.	n.a.	n.a.	71
para‐47 c	0.5 (0.3–1.0)	n.a.	n.a.	n.a.	0.9 (0.6–1.0)	n.a.	9.0 (4.3–7.3)	13.6 (3.7–27.4)	33.6 (27.4–42.4)	72
ortho‐47 c	0.3 (0.2–0.3)	n.a.	n.a.	n.a.	0.4 (0.2–0.3)	n.a.	2.6 (1.2–4.0)	9.4 (9.0–9.8)	n.a.	72
meta‐47 c	0.6 (0.5–0.7)	n.a.	n.a.	n.a.	0.6 (0.5–0.6)	n.a.	3.4 (2.1–4.7)	1.3 (0.5–2.1)	n.a.	72

^a ID/organ %, rats, n = 4.

^b ID/organ %, rats, n = 4, 6, 5, 3.

^cID/g %, dogs, n = 3.