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. 2017 Apr 8;45(11):6388–6403. doi: 10.1093/nar/gkx234

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Published by Oxford University Press on behalf of Nucleic Acids Research 2017.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 3. — Dynamic enhancer epigenome correlates with the dynamic transcriptome during adipogenesis. (A–D) Characterization of the dynamic transcriptome. Genes are clustered according to their dynamic expression pattern during adipogenesis. (A) Heat map of clustered gene expression during adipogenesis. The number of genes in each group is indicated. (B) Temporal profile of average relative expression levels for each group of genes. (C) Gene ontology (GO) analysis of each group of genes. (D) Expression levels of a representative gene for each gene group during adipogenesis. (E) Dynamic epigenome correlates well with the dynamic transcriptome during adipogenesis. Shown are heat maps of average gene expression levels determined by RNA-Seq, H3K4me1/2 and H3K27ac levels on enhancers, H3K4me3 levels on promoters, H3K36me3 levels over gene bodies and overall (gene body, promoter and distal region) H3K27me3 levels for the five groups of genes during adipogenesis.