Table 7.
Factors Associated With Coronary Plaque Features in the HIV-Infected Cohort Determined by Multivariables Regression Modelsa
| Parameter | Order Parameter Entered in the Model | Total Plaque Segments | Noncalcified Plaque Segments | |||
|---|---|---|---|---|---|---|
| β-Estimate | P Value | β-Estimate | P Value | |||
| Race (white vs non-white) | 1 | 0.561 | .01 | |||
| Age | 2 | 0.097 | .001 | 2 | 0.031 | .10 |
| Smoking status (yes vs no) | 4 | 0.413 | .05 | |||
| Sex (male vs female) | ||||||
| Current diabetes mellitus (yes vs no) | ||||||
| Current hypertension (yes vs no) | ||||||
| LDL, mg/dL | ||||||
| HDL, mg/dL | ||||||
| Triglycerides, mg/dL | ||||||
| BMI, kg/m2 | ||||||
| MCP-1, pg/mL | 5 | 0.003 | .06 | |||
| hsCRP, mg/L | ||||||
| oxLDL, U/L | ||||||
| Lp-PLA2 activity, nmol/(min × mL) | ||||||
| Log+1 aspartame, mg/day | 3 | 0.512 | .03 | 1 | 0.439 | .002 |
Abbreviations: BMI, body mass index; HIV, human immunodeficiency virus; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein; Lp-PLA2, lipoprotein-associated phospholipase A2; MCP-1, monocyte chemoattractant protein 1.
aR2 = 0.27 for total plaque segments, R2 = 0.10 for noncalcified plaque segments. Covariates without data listed did not enter the model.