Table 2.
Parameter changes after 42-week trial
| Parameters | SG (N=50) | CG (N=50) | SCG (N=50) | PG (N=50) | t-value | P-value |
|---|---|---|---|---|---|---|
| Weight (kg) | 84.4±15.7 | 82.1±14.9 | 82.0±17.6 | 85.2±14.0 | 1.79 | 0.015 |
| BMI (kg/m2) | 26.4±1.2 | 26.8±1.4 | 24.5±1.5 | 28.6±1.9 | 1.23 | 0.027 |
| FBG (mmol/L) | 7.9±1.1 | 8.0±1.0 | 7.3±1.0 | 8.6±1.3 | 2.01 | 0.018 |
| 2hPG (mmol/L) | 12.4±1.5 | 13.5±1.9 | 10.4±1.7 | 14.4±1.8 | 0.85 | 0.022 |
| HbAlc (%) | 7.5±0.9 | 7.0±0.8 | 6.8±0.9 | 8.7±0.8 | 0.74 | 0.037 |
| TG (mmol/L) | 2.2±1.3 | 2.4±1.1 | 1.8±1.0 | 2.6±1.3 | 0.75 | 0.030 |
| TC (mmol/L) | 5.2±2.3 | 5.5±1.8 | 4.5±1.6 | 6.0±1.9 | 0.63 | 0.021 |
| HDL (mmol/L) | 1.5±0.8 | 1.4±0.6 | 1.6±0.5 | 1.4±0.3 | 0.23 | 0.143 |
| LDL (mmol/L) | 3.9±1.7 | 3.6±1.1 | 2.8±1.0 | 4.5±1.2 | 0.81 | 0.042 |
| FINS (pmol/L) | 124.6±45.7 | 127.6±39.3 | 119.4±37.9 | 138.5±36.4 | 0.97 | 0.025 |
| HOMA-IR | 5.8±2.4 | 6.0±2.4 | 4.5±2.5 | 6.3±2.9 | 1.08 | 0.031 |
| HOMA-IS | 80.3±54.2 | 78.3±50.9 | 91.6±43.8 | 70.3±52.3 | 2.97 | 0.016 |
| Fasting c peptide (nmol/L) | 1.2±0.5 | 1.1±0.4 | 1.1±0.3 | 1.1±0.4 | 0.11 | 0.092 |
| 2-hour postprandial c peptide (nmol/L) | 2.57±1.1 | 2.84±1.2 | 2.73±1.2 | 2.86±1.3 | 0.44 | 0.074 |
| Resistin (ng/mL) | 11.34±0.51 | 13.18±0.44 | 7.15±0.36 | 16.22±0.38 | 3.21 | 0.001 |
| Adiponectin (pg/mL) | 158.5±7.6 | 142.5±8.5 | 172.1±10.8 | 123.4±7.6 | 1.22 | 0.044 |
| C-reactive protein (mg/L) | 5.1±0.6 | 5.4±0.5 | 4.2±0.4 | 6.2±0.5 | 3.64 | 0.007 |
| TNF-α (pg/mL) | 312.7±19.9 | 326.4±17.3 | 280.1±16.4 | 345.6±18.2 | 3.89 | 0.005 |
Notes: ANOVA was performed to compare the variance among four groups. Data presented as mean ± SD. There are significant statistic differences at P<0.05.
Abbreviations: SCG, sitagliptin and chitosan oligosaccharide group; CG, chitosan oligosaccharide group; SG, sitagliptin group; PG, placebo group; ANOVA, analysis of variance; SD, standard deviation; BMI, body mass index; FBG, fasting blood glucose; HbAlc, hemoglobin A1c; TG, triglyceride; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FINS, fasting insulin; HOMA-IR, insulin resistance index; HOMA-IS, insulin secre tory activity; TNF, tumor necrosis factor; 2hPG, two-hour plasma glucose.