Table 2. List of known RBPs in E. coli.

Protein name	Reference	Domains	Domain coverage (%)	Residue similarity (%)	Residue identity (%)
Hfq	Chao et al. (21)	RRM_RBM7	41.33	25.33	17.33
CsrA	Romeo et al. (22)	CsrA	84.06	72.46	49.28
ProQ	Chaulk et al. (58), Smirnov el al. (59)	ProQ/FINO family	100.00	66.67	55.26
YhbY	Ostheimer et al. (56)	RNA_bind_YhbY	97.89	89.47	80.00
SmpB	Wower et al. (57)	SsrA-binding domain	99.31	67.36	46.53
CspA	Phadtare et al. (60)	Cold shock domain	98.51	77.61	67.16
CspB	Phadtare et al. (60)	Cold shock domain	97.01	73.13	67.16

These RBPs consist of well-defined RBDs. Hence, as shown in the table they were predicted to have higher coverage and similarity when compared with their reference domains.