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. 2017 May 4;4(2):ofx093. doi: 10.1093/ofid/ofx093

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© The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 3. — The rate of change (slope) in susceptibility/resistance during the times of significant change. First derivative (ie, slope) of the fitted spline. The gray band is a 95% simultaneous confidence interval. Sections of the slope where the (gray-shaded) confidence interval does not include zero are 2 periods of statistically significant change in percentage resistance. The curve in blue corresponds to the derivative line being above the zero horizontal line and, hence, marks a significant increase in (centered, × 100) resistance, and the curve in red corresponds to the derivative line being below the zero line and, therefore, indicates a period of significant decrease in resistance.