Table 2. Real and CPU time needed to run PosiGene on the real datasets analyzed in this work.

	4-species set		9-species set
	Real time	CPU time	Real time	CPU time
M1: building the ortholog catalog	1.8 h	1.1 h	17.1 h	305.3 h
M2: alignments and phylogeny	6.6 h	125.1 h	26.8 h	565.6 h
M3: positive selection and filtering	5.1 h	95.7 h	33.9 h	799.5 h
∑	13.5 h	221.9 h	77.8 h	1670.4 h

Note: the table shows the real and CPU times consumed by two PosiGene runs that were executed on species sets of different sizes. A server with 24 processors was used for both runs.