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. 2017 May 16;45(11):6613–6627. doi: 10.1093/nar/gkx417

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 10. — Model of the role of MYB15 in cold stress signaling. Under normal conditions, ICE1 is ubiquitinated by HOS1 and degraded by the 26S-proteasome pathway, whereas MYB15 binds to an MYBRE on the promoters of CBF genes to inhibit their transcription. In response to cold stress, MYB15 is phosphorylated by cold-activated MPK6 and released from the CBF gene promoters. ICE1 is stabilized by SIZ1-mediated sumoylation and sumoylated ICE1 binds to an MYCRE on the CBF promoters, leading to their increased expression and increased freezing tolerance. CBFs, C-repeat binding factors (an AP2-type transcription factors); MYBRE, MYB transcription factor recognition element; MYCRE, MYC transcription factor recognition element; P, phosphorylation; S, sumoylation; U, ubiquitination.