Table 2.

Safety Reports

Reference	Treatment	Patient No.	Study Design	ADE	ADE Rate	Median Time to ADE
Varada, Sakoulas, Lei. 2015. [29]	CPT 600mg q8-12h + CLI	55	Retrospective review	Neutropenia	7.3%	22 days	ANC 0cells/mm3 for all patients
LaVie et al. 2015. [30]	CPT 600mg q8-12h	39	Retrospective review	Neutropenia	18%	24 days	10% of patients developed ANC < 500 cells/mm3
Jain et al. 2014. [31]	CPT 600mg q8-12h	12	Retrospective review	Neutropenia Anemia Severe rash	33.3% 33.3% 16.6%	22 days	—
Furtek et al. 2016. [32]	CPT	67	Retrospective review	Neutropenia	14% 21%	≥14 days ≥21 days	ANC ranged from 0-1605cells/mm3

Abbreviations: ANC, absolute neutrophil count; CLI, clindamycin; CPT, ceftaroline

^aPatients in all four studies had received a variety of concomitant antimicrobials throughout therapy.