Table 1.

Currently available iron chelators [18–22].

	Deferoxamine	Deferasirox	Deferiprone
Structure
Administration route	Subcutaneousa	Oral	Oral
Recommended dose for transfusional iron overload	1000–2000 mg (20–40 mg/kg/day)	Deferasirox DT  Starting dose: 20 mg/kg/day  Maximum dose: 40 mg/kg/day Deferasirox FCT  Starting dose: 14 mg/kg/day  Maximum dose: 28 mg/kg/day	25–33 mg/kg TID (75–99 mg/kg/day)
Half-life	18–20 minutes	8–16 hoursb	1.9 hours
Approximate daily iron cleared	0.05–0.19 mg Fe/kg body weight/day	0.1–0.5 mg Fe/kg body weight/dayb	0.03–0.4 mg/kg body weight/day
Elimination	Primarily urine	Primarily fecalb	Primarily urine

DT, dispersible tablet; FCT, film-coated tablet; TID, 3 times a day.

^aRecommended; may also be administered intravenously and intramuscularly.

^bStudies were performed using deferasirox DT for oral suspension.