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Curcumin could rescue the induction of EMT via suppressing of Hedgehog signaling pathway. With the treatment of 18 Gy γ-irradiation for 96 hours, EMT process of cells was reversed. The expression of β-catenin and Vimentin were restrained. The expression of E-cadherin and Claudin were recovered. The expression of Gli1 and SMO were inhibited, and that of Sufu which acted as an inhibitor of Gli1 was increased. * meant P value was less than 0.05 compared with NC group.
