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. 2017 May 2;16(12):1181–1192. doi: 10.1080/15384101.2017.1320000

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Figure 6. — In addition with Curcumin (20 μM) and γ-irradiation (18Gy) as combined therapy, Curcumin did not reverse the formation of early apoptosis promoted by γ-irradiation. In LN229, Curcumin could advance the cytotoxic effect of γ-irradiation remarkably, however this phenomenon was slightly in U251. (A) The cell proliferation assay showed the promotion of Curcumin was remarkable in LN229, while that of U251 was slightly. The bar graph merged 2 cell line together for a more intuitive observation. (B) Cell apoptosis assay showed the combined therapy had limited influence on early apoptosis of U251, however it was more effective in LN229. * meant P value was less than 0.05 compared with NC group. (C) A model for Curcumin increasing the efficiency of γ-irradiation by regulating Hedgehog signaling pathway.