Figure 2.

Structure and functional implication of paraspeckles in the rhythmic expression of mRNA. Paraspeckles are schematically drawn as oblong structures organized around the short (Neat1–1) and long (Neat1–2) transcripts of the long non-coding Neat1 RNA. Major protein entities of paraspeckles are also shown in the scheme. The roles of paraspeckles in circadian gene expression is schematically represented. The rhythmic number of paraspeckles inside the cells drives a circadian nuclear retention of paraspeckles-associated mRNA and thus leads to a circadian gene expression.