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Experiment 1. Time-response curves on the tail withdrawal test in male rats (left), female rats (center) and both sexes combined (right). CBD was administered 15 min before THC. THC-induced antinociception was greater in females than males, with no significant CBD enhancement of THC’s effect in either sex. Each point is the mean ± 1 S.E.M of 10 male or female rats (left and center panels), or 20 total rats (right panel).
