Table 4. Univariate and multivariate regression analysis of risk factors for bleeding after endoscopic submucosal dissection.

Factor	Univariate analysis		Multivariate analysis
	OR (95 %CI)	P value	OR (95 %CI)	P value
Age (> 75 years)	0.4 (0.1 – 0.9)	0.037	0.2 (0.06 – 0.6)	0.001
Sex (male)	1.2 (0.5 – 3.8)	0.68
Location of maximum legion (L/U,M)	1.9 (0.9 – 4.4)	0.09
Maximum lesion size (> 20 mm)	2.1 (0.9 – 4.6)	0.07
More than 2 legions	1.5 (0.3 – 4.6)	0.53
Aspirin	4.8 (1.9 – 11.3)	0.002
Thienopyridine	6.9 (1.8 – 21.3)	0.007	4.4 (0.7 – 22.5)	0.11
Other antiplatelet agents	1.0 (0.2 – 3.4)	0.96
Anticoagulants	5.5 (1.5 – 16.6)	0.014
Dual antiplatelet therapy	10.6 (3.1 – 32.3)	0.001	10.9 (2.1 – 49.5)	0.005
Heparin replacement	14.8 (4.6 – 44.1)	< 0.001	34.4 (9.4 – 133.2)	< 0.001
Cardiovascular disease	4.3(1.8 – 9.7)	0.001
Chronic renal disease	3.3 (0.7 – 10.6)	0.10
Neurological disease	1.5 (0.3 – 4.6)	0.53
Hypertension	1.2 (0.5 – 2.6)	0.70
Diabetes mellitus	2.8 (1.1 – 6.3)	0.026

OR, odds ratio; CI, confidence interval; U, upper; M, middle; L, Lower.