Figure 2.

Increased expression of Sox2 can rescue Sox3 null pituitary defects. (A) Adult pituitaries showing dorsal displacement of the neural lobe in Sox3^KO/Y mice. (B) Haemotoxylin and eosin staining of 8-week-old pituitary coronal sections. Asterisk highlights abnormal clefting. Arrowhead indicates hypoplastic anterior lobe. (C) Phase contrast images of 12.5 dpc developing pituitaries (saggital sections). (D) Quantification of infundibulum width of 12.5 dpc embryos (n = 3). One-way ANOVA using Tukey’s Multiple comparison test. Mean ± SEM.