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. 2017 May 17;206(3):1495–1503. doi: 10.1534/genetics.117.202549

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SOX2 regulates SOX3 target genes in the mouse testes. (A) Sox2 qPCR analysis in 2 week Sox3^+/Y and Sox3^Sox2KI/Y testes [Student’s two tailed unpaired t-tests (****<0.0001)]. (B) qPCR analysis of Sox3 3′ UTR in 2 week Sox3^+/Y and Sox3^Sox2KI/Y testes [Student’s two-tailed unpaired t-tests (**<0.01)]. (C) SOX2 and SOX3 immunostaining on Sox3^+/Y, Sox3^KO/Y and Sox3^Sox2KI/Y 4-week-old testes. (D) Microarray analysis was performed on 2 week testes from Sox3^+/Y, Sox3^KO/Y and Sox3^Sox2KI/Y, and two-way comparisons were performed between Sox3^+/Y and either Sox3^Sox2KI/Y or Sox3^KO/Y. Genes presented were significantly different between Sox3^+/Y and Sox3^KO/Y testes (Step-up P value <0.05). * <0.05 step-up P value between Sox3^KO/Y and Sox3^Sox2KI/Y. (E) qPCR validation of SOX2 regulation of SOX3 target genes in 2 week testes. ANOVA multiple comparisons with Bonferroni’s correction were performed using Graphpad Prism (****<0.0001, ***<0.001, **<0.01, *<0.05, ns, not significant).