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Many metaphases in topo II-depleted cells have one or more elongated chromosome arms stretched towards the spindle pole. (A) A control (topo IIα and IIβ-expressing) HTETOP metaphase cell; (B)-(C) HTETOP topo IIα-depleted metaphase cells (48 hours dox); (D)-(E) topo IIα (72 hours dox) and topo IIβ (72 hours siRNA)-depleted cells arrested in metaphase with MG132 (DNA/DAPI – blue; tubulin, α or γ as indicated – red; CENP-C – green). Scale bar, 10 μm.
