Table 3. Association of cardiometabolic traits and synchrony measures.

	Longitudinal segmental synchrony		Transverse segmental synchrony
	estimate (s.e.)	P	estimate (s.e.)	P
Primary traits
Body mass index	0.02 (0.005)	0.003	0.01 (0.006)	0.11
Triglycerides	-0.003 (0.005)	0.59	-0.003 (0.006)	0.63
HOMA-IR	0.02 (0.008)	0.05	0.02 (0.009)	0.05
C-reactive protein	0.0003 (0.005)	0.96	-0.006 (0.006)	0.31
Secondary traits
Waist circumference	0.03 (0.01)	0.006	0.01 (0.01)	0.42
Fasting glucose	-0.008 (0.006)	0.20	-0.01 (0.007)	0.09
HDL cholesterol	-0.007 (0.006)	0.21	-0.02 (0.007)	0.008
Diabetes mellitus	0.08 (0.02)	<0.0001	0.05 (0.02)	0.02
Adiponectin	0.0006 (0.005)	0.90	0.004 (0.006)	0.54
Leptin	0.01 (0.007)	0.15	0.01 (0.008)	0.07
Leptin receptor	-0.001 (0.004)	0.76	-0.006 (0.005)	0.20
Aldosterone/renin ratio	0.006 (0.004)	0.14	-0.007 (0.005)	0.14

Beta estimate represents the change in echo variable (synchrony expressed in ms) per 1-standard deviation change in continuous clinical traits, and for the presence versus absence of dichotomous traits. Multivariable model adjusted for age, sex, body mass index, heart rate, systolic blood pressure, hypertension treatment, diabetes mellitus, HDL cholesterol, triglyceride concentrations. Biomarkers are log-transformed.