Skip to main content
. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Nat Rev Rheumatol. 2016 Aug 19;12(10):580–592. doi: 10.1038/nrrheum.2016.136

Figure 4. Targeting low-grade inflammation in OA.

Figure 4

Can abrogating low-grade inflammatory responses break the feed-forward cycle of joint damage and breakdown leading to inflammation that promotes the pathogenesis of OA? Examples of risk factors for OA, cell types involved in its pathogenesis, and molecular components in the inflammatory pathways that are potential therapeutic targets for preventing or treating OA are shown. CPB, carboxypeptidase B; DAMPs, disease-associated molecular patterns; NO, nitric oxide; OA, osteoarthritis.